Nuzlocke is a full-playthrough challenge in Paper Mario: The Thousand-Year Door. In this run, the player plays through the game under Nuzlocke conditions: if any partner falls to 0 HP during battle, he or she cannot be used in battle for the remainder of the game.
- If any of Mario's Partners reach 0 HP during battle, do not use them in battle again.
Nuzlocke has been completed by the following players:
|Game Completion||Pit Completion|